Pop Cryptid trivia answers
From Pop Cryptid Spectator 18:
What actress has appeared in TWO movies as a cancer-stricken wife of a man who embarks on a personal journey involving a cryptid?
Debra Messing. She played Mary Klein in The Mothman Prophecies (2002) and Thea Linnea Pyle in The Dark Divide, a 2020 movie based on the memoir Where Bigfoot Walks: Crossing the Dark Divide by Robert Pyle. While neither movie was primarily about the cryptid aspect, I thought this was an interesting commonality.